CADUSAFOS

Description

This nonsystemic organophosphate not registered for U.S. usage is used to control nematodes and soil insects on bananas and other crops in several countries. The U.S. EPA has granted tolerances for cadusafos in imported bananas, where it provides excellent control of the burrowing nematode, Radopholus similis (22). Cadusafos reportedly possesses reduced risk for contaminating groundwater and provided good control of the citrus nematode, Tylenchulus semipenetrans (23). Cadusafos is commercially available in granular and microencapsulated formulations.

The Uses of CADUSAFOS

CADUSAFOS is used in the agriculture industry

The Uses of CADUSAFOS

Insecticide; nematocide.

The Uses of CADUSAFOS

Cadusafos is used to control nematodes, cutworms and soil insects in bananas, citrus, maize, potatoes, tobacco, sugar cane and vegetables.

Definition

ChEBI: Cadusafos is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nematicide and an agrochemical.

General Description

Cadusafos is a nematicide used in controlling nematodes, soil insects and cutworms in a variety of fruits and vegetables. Its mode of action involves the inhibition of acetylcholinesterase.

Metabolic pathway

There is little published information on the metabolism of cadusafos. What has been published suggests that the main route of metabolism in animals is via hydrolysis to give 1-methyl-1-propanethiol which is then thiooxidised.

Metabolism

The acute oral LD₅₀ values for rats and mice are 37.1 and 71.4 mg/kg, respectively. Inhalation LC50 (4 h) for rats is 0.026 mg/L air. NOEL (2 yr) for rats is 1 mg/kg diet (0.05 mg/kg/d) and ADI is 0.3 μg/kg. In mammals, it is readily metabolized and is eliminated in the urine and feces. The major metabolic route is hydrolysis to give 1-methyl-1-propanothiol, followed by oxidation. The halflife in soils is 11–55 d.