CA-224
- CAS NO.：883561-04-4
- Empirical Formula: C24H22N2O
- Molecular Weight: 354.44
- Update Date: 2026-04-22 18:57:36
What is CA-224?
Description
CA-224 is potent CDK4 inhibitor, is also a nonplanar analogue of fascaplysin that specifically inhibits Cdk4-cyclin D1 in vitro. CA-224 blocks the growth of cancer cells at G0/ G1 phase of the cell cycle. CA-224 also blocks the cell cycle at G2/M phase, which is explained by the fact that it inhibits tubulin polymerization. Additionally, CA-224 acts as an enhancer of depolymerization for taxol-stabilized tubulin. CA-224 selectively induces apoptosis of SV40 large Tantigen. transformed cells and significantly reduces colony formation efficiency, in a dose-dependent manner, of lung cancer cells. The promising efficacy of CA-224 in human xenograft models as well as its excellent therapeutic window indicates its potential for clinical development.
Properties of CA-224
| Melting point: | 178 °C |
| Boiling point: | 608.8±48.0 °C(Predicted) |
| Density | 1.182±0.06 g/cm3(Predicted) |
| pka | 17.15±0.30(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for CA-224
Computed Descriptors for CA-224
New Products
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