c-GpAp

CAS NO.：849214-04-6
Empirical Formula: C20H24N10O13P2
Molecular Weight: 674.41
MDL number: MFCD28411367
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 23:24:14

What is c-GpAp?

The Uses of c-GpAp

c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA.

The Uses of c-GpAp

cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay.

Definition

ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-).

Biochem/physiol Actions

cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment.

Storage

+4°C

Properties of c-GpAp

Boiling point:	1159.9±75.0 °C(Predicted)
Density	2.61±0.1 g/cm3(Predicted)
storage temp.	-20°C
form	powder
pka	0.96±0.70(Predicted)
color	white to beige
Water Solubility	Water : 20 mg/mL (29.66 mM)

Safety information for c-GpAp

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.