Butyl chloroformate
- CAS NO.：592-34-7
- Empirical Formula: C5H9ClO2
- Molecular Weight: 136.58
- MDL number: MFCD00000650
- EINECS: 209-750-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-12 17:28:22
What is Butyl chloroformate?
Chemical properties
clear liquid
The Uses of Butyl chloroformate
Butyl Chloroformate is a reactant in the preparation of Lapatinib derivatives as HER1/HER2 targeting antitumor drugs.
General Description
A colorless liquid. Flash point near 70°F. Very toxic by inhalation. Denser than water. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Decomposes exothermically in water to give hydrochloric acid and organic acids.
Reactivity Profile
Butyl chloroformate is incompatible with bases (including amines), with water, with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
Inhalation of vapor irritates nose and throat and can cause delayed pulmonary edema. Liquid irritates eyes and causes severe skin burns and irreversible skin damage if allowed to remain. Can cause blindness. Ingestion causes burns of mouth and stomach.
Flammability and Explosibility
Flammable
Properties of Butyl chloroformate
| Melting point: | -70 °C |
| Boiling point: | 142 °C(lit.) |
| Density | 1.074 g/mL at 25 °C(lit.) |
| vapor pressure | 2.42 psi ( 20 °C) |
| refractive index | n |
| Flash point: | 77 °F |
| storage temp. | 2-8°C |
| form | Liquid |
| color | Clear |
| Water Solubility | DECOMPOSES |
| Sensitive | Moisture Sensitive |
| BRN | 605635 |
| CAS DataBase Reference | 592-34-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbonochloridic acid, butyl ester(592-34-7) |
| EPA Substance Registry System | n-Butyl chloroformate (592-34-7) |
Safety information for Butyl chloroformate
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation H331:Acute toxicity,inhalation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Butyl chloroformate
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