BUSERELIN
Synonym(s):Buserelin acetate salt;des-Gly10-[D -Ser[t-Bu]6]-LH-RH ethylamide acetate salt;pGlu-His-Trp-Ser-Tyr-D -Ser(t-Bu)-Leu-Arg-Pro-NHEt acetate salt
- CAS NO.：68630-75-1
- Empirical Formula: C62H90N16O15
- Molecular Weight: 1299.5
- MDL number: MFCD01716229
- EINECS: 636-185-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-21 10:31:43
What is BUSERELIN?
Description
Buserelin acetate is a potent analog of the hypothalamic hormone, luteinizing hormone-releasing hormone (LH-RH). Chronic administration of higher doses of buserelin desensitizes the pituitary, resulting in a decreased production of luteinizing hormone (LH), follicle stimulating hormone (FSH), and eventually sex steroids (testosterone in males and estradiol in females). Initial approval is for use in achieving medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of endometriosis, leiomyoma, precocious puberty, advanced breast cancer and infertility.
Chemical properties
White Solid
Originator
Hoechst AG (W. Germany)
The Uses of BUSERELIN
Gondadotropin-releasing hormone agonist, used to treat hormone-responsive cancers such as prostate and breast cancer. Synthetic nonapeptide agonist analog of LH-RH. Antineolpastic (hormonal).
Definition
ChEBI: Buserelin acetate is an organic molecular entity.
brand name
Suprefact (Hoechst-Roussel).
Biochem/physiol Actions
Buserelin is an LH-RH agonist.
Properties of BUSERELIN
| Melting point: | 186-188°C |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for BUSERELIN
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H360:Reproductive toxicity |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for BUSERELIN
BUSERELIN manufacturer
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