Bupranolol
- CAS NO.：14556-46-8
- Empirical Formula: C14H22ClNO2
- Molecular Weight: 271.78
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-04 14:24:59
What is Bupranolol?
Originator
Betadrenol,Pharma-Schwarz,W. Germany,1969
The Uses of Bupranolol
Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.
Definition
ChEBI: Bupranolol is an aromatic ether.
Manufacturing Process
A mixture of 16.3 g of (2-chloro-5-methylphenyl)glycidic ether (from epichlorohydrin and 2-chloro-5-methylphenol) and 6.2 g of t-butylamine in 50 ml of ethanol is heated at reflux for 6 hours. The solvent is removed, the residue is washed with water and then extracted with benzene. The dried extract is evaporated to give 1-t-butylamino-3-(2-chloro-5-methylphenoxy)-2- propanol. Treatment of the free base in benzene solution with dry hydrogen chloride yields the hydrochloride salt.
Therapeutic Function
Antiarrhythmic
Properties of Bupranolol
| Melting point: | 71-74°C |
| Boiling point: | 396.3±42.0 °C(Predicted) |
| Density | 1.098±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, Refrigerator, Under Inert Atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.82±0.20(Predicted) |
| color | White to Off-White |
Safety information for Bupranolol
Computed Descriptors for Bupranolol
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