Brinzolamide-d5
- CAS NO.：1217651-02-9
- Empirical Formula: C12H21N3O5S3
- Molecular Weight: 383.5
- Update Date: 2025-08-20 16:56:13
What is Brinzolamide-d5?
Description
Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.
Chemical properties
Crystalline Solid
The Uses of Brinzolamide-d5
Carbonic anhydrase inhibitor. Antiglaucoma agent.
What are the applications of Application
Brinzolamide-d5 is an inhibitor of CA II (carbonic anhydrase II)
Properties of Brinzolamide-d5
| storage temp. | Refrigerator |
| solubility | Ethanol |
| form | Solid |
| color | Crystalline |
Safety information for Brinzolamide-d5
Computed Descriptors for Brinzolamide-d5
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