tert-Butoxy bis(dimethylamino)methane

Synonym(s):Bredereck’s reagent

CAS NO.：5815-08-7
Empirical Formula: C9H22N2O
Molecular Weight: 174.28
MDL number: MFCD00042858
EINECS: 227-383-9
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

tert-Butoxy bis(dimethylamino)methane Structural

What is tert-Butoxy bis(dimethylamino)methane?

Chemical properties

Clear pale yellow liquid

The Uses of tert-Butoxy bis(dimethylamino)methane

Reactant for:• ;Preparation of pyrroloquinazolines as photochemotherapeutic agents1• ;Enanatioslective formal synthesis of the Cinchona alkaloid quinine via stereoselective intermolecular radical addition2• ;Synthesis of camptothecin via intramolecular isomuenchnone cycloaddition reaction3• ;Aminomethylenation reactions4

The Uses of tert-Butoxy bis(dimethylamino)methane

Mild enamination reagent; catalyst in ring-opening polymerization reactions.

The Uses of tert-Butoxy bis(dimethylamino)methane

Reactant for:

Preparation of pyrroloquinazolines as photochemotherapeutic agents
Enanatioslective formal synthesis of the Cinchona alkaloid quinine via stereoselective intermolecular radical addition
Synthesis of camptothecin via intramolecular isomuenchnone cycloaddition reaction
Aminomethylenation reactions

Properties of tert-Butoxy bis(dimethylamino)methane

Boiling point:	50-55 °C/15 mmHg (lit.)
Density	0.844 g/mL at 25 °C (lit.)
refractive index	n20/D 1.422(lit.)
Flash point:	106 °F
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly)
pka	5.46±0.38(Predicted)
form	Liquid
color	Clear pale yellow
Specific Gravity	0.844
BRN	1901973
Stability:	Hygroscopic
InChI	InChI=1S/C9H22N2O/c1-9(2,3)12-8(10(4)5)11(6)7/h8H,1-7H3
CAS DataBase Reference	5815-08-7(CAS DataBase Reference)

Safety information for tert-Butoxy bis(dimethylamino)methane

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.