BMX-IN-1

CAS NO.：1431525-23-3
Empirical Formula: C29H24N4O4S
Molecular Weight: 524.59
MDL number: MFCD25372042
Update Date: 2026-04-22 18:57:36

What is BMX-IN-1?

Description

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX; IC₅₀ = 8 nM) that targets Cys⁴⁹⁶ in the BMX ATP binding domain. It additionally targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent for inhibition of Blk, JAK3, EGFR, Itk, or Tec activity. BMX-IN-1 was shown to inhibit the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with a GI₅₀ value of 25 nM. Antiproliferative activity was also observed in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines (GI₅₀s = 2.54, 4.38, 5.37, and 2.46 μM, respectively).

Storage

Store at -20°C

Properties of BMX-IN-1

Density	1.397±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥5.25 mg/mL in DMSO
form	solid
pka	7.77±0.10(Predicted)
color	White to yellow

Safety information for BMX-IN-1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BMX-IN-1

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