Bis(2-nitrophenyl) disulfide

Synonym(s):2-Nitrophenyl disulfide

CAS NO.：1155-00-6
Empirical Formula: C12H8N2O4S2
Molecular Weight: 308.33
MDL number: MFCD00007130
EINECS: 214-581-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:25:52

What is Bis(2-nitrophenyl) disulfide?

Chemical properties

yellow to yellow-green crystalline powder

The Uses of Bis(2-nitrophenyl) disulfide

Bis(o-Nitrophenyl) Disulfide, can be used in a PVC membrane electrode as a sensor for zinc ions. It is also a building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of a series of 4-Azaindole inhibitors of c-Met kinase.

General Description

PVC membrane electrode based on bis(2-nitrophenyl)disulfide carrier acts as sensor for zinc ions. Bis(2-nitrophenyl) disulphide undergoes mechanochemical grinding with bis(4-chlorophenyl)disulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene catalyst via metathesis reaction to yield non-symmetrical heterodimer 4-chlorophenyl-2′-nitrophenyl disulfide.

Purification Methods

Purify the disulfide by recrystallisation from glacial AcOH or from *C6H6 and the yellow needles are dried in an oven at 100o until the odour of the solvent is absent. It is sparingly soluble in EtOH and Me2CO. [Bogert & Stull Org Synth Coll Vol I 220 1941, Bauer & Cymerman J Chem Soc 3434 1949, Beilstein 6 IV 1672.]

Properties of Bis(2-nitrophenyl) disulfide

Melting point:	194-197 °C (lit.)
Boiling point:	441.9±30.0 °C(Predicted)
Density	1.62 g/cm3 (-123.16℃)
refractive index	1.6510 (estimate)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
color	Light yellow to Brown
BRN	1016770
CAS DataBase Reference	1155-00-6(CAS DataBase Reference)
NIST Chemistry Reference	Bis(o-nitrophenyl)disulfide(1155-00-6)
EPA Substance Registry System	Disulfide, bis(2-nitrophenyl) (1155-00-6)

Safety information for Bis(2-nitrophenyl) disulfide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.