Bis(2-chloroethyl)amine hydrochloride

Synonym(s):Bis(2-chloroethyl)amine hydrochloride;Bis(2-chloroethyl)ammonium chloride

CAS NO.：821-48-7
Empirical Formula: C4H10Cl3N
Molecular Weight: 178.49
MDL number: MFCD00012515
EINECS: 212-479-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-17 14:35:14

Bis(2-chloroethyl)amine hydrochloride Structural

What is Bis(2-chloroethyl)amine hydrochloride?

Chemical properties

white to beige crystalline powder

The Uses of Bis(2-chloroethyl)amine hydrochloride

Bis(2-chloroethyl)amine hydrochloride is used as an intermediate chemical synthesis and building block for piperazine derivatives. It is a cytotoxic metabolite of Cyclophosphamide, a deuterated analogue of Nor-nitrogen mustard.

Safety Profile

A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.

Description

Bis(2-chloroethyl)amine hydrochloride is used as a Key raw material in manufacturing Piperazine derivatives. It is used to manufacture APls like Aripiprazole,Batoprazine,Cyclophosphamide,Eltoprazine hydrochloride，Estramustine phosphate，lfosfamide,ltraconazole, Ketoconazole, Lensiprazine, Naluzotan,Trazodone.

Purification Methods

Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,

Properties of Bis(2-chloroethyl)amine hydrochloride

Melting point:	212-214 °C(lit.)
storage temp.	Store below +30°C.
solubility	>100g/l
form	Crystalline Powder
color	White to beige
Water Solubility	SOLUBLE
Sensitive	Hygroscopic
BRN	3550356
CAS DataBase Reference	821-48-7(CAS DataBase Reference)
NIST Chemistry Reference	2,2'-Dichlorodiethylamine hydrochloride(821-48-7)
EPA Substance Registry System	Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7)

Safety information for Bis(2-chloroethyl)amine hydrochloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H290:Corrosive to Metals H302:Acute toxicity,oral H314:Skin corrosion/irritation
Precautionary Statement Codes	P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.