Bis(2-chloroethyl)amine hydrochloride
Synonym(s):Bis(2-chloroethyl)amine hydrochloride;Bis(2-chloroethyl)ammonium chloride
- CAS NO.：821-48-7
- Empirical Formula: C4H10Cl3N
- Molecular Weight: 178.49
- MDL number: MFCD00012515
- EINECS: 212-479-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:23
What is Bis(2-chloroethyl)amine hydrochloride?
Chemical properties
white to beige crystalline powder
The Uses of Bis(2-chloroethyl)amine hydrochloride
Bis(2-chloroethyl)amine hydrochloride is used as an intermediate chemical synthesis and building block for piperazine derivatives. It is a cytotoxic metabolite of Cyclophosphamide, a deuterated analogue of Nor-nitrogen mustard.
Safety Profile
A poison by inhalation,intraperitoneal, intramuscular, and subcutaneous routes.An experimental teratogen. Human mutation datareported. When heated to decomposition it emits toxicfumes of NH3, NOx, and Cl-.
Description
Bis(2-chloroethyl)amine hydrochloride is used as a Key raw material in manufacturing Piperazine derivatives. It is used to manufacture APls like Aripiprazole,Batoprazine,Cyclophosphamide,Eltoprazine hydrochloride，Estramustine phosphate，lfosfamide,ltraconazole, Ketoconazole, Lensiprazine, Naluzotan,Trazodone.
Purification Methods
Crystallise the salt from Me2CO or MeOH/Et2O. The picrate has m 112-113o (from EtOH or Me2CO). [Mann J Chem Soc 464 1934, Ward J Am Chem Soc 57 915 1935,
Properties of Bis(2-chloroethyl)amine hydrochloride
| Melting point: | 212-214 °C(lit.) |
| storage temp. | Store below +30°C. |
| solubility | >100g/l |
| form | Crystalline Powder |
| color | White to beige |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| BRN | 3550356 |
| CAS DataBase Reference | 821-48-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2,2'-Dichlorodiethylamine hydrochloride(821-48-7) |
| EPA Substance Registry System | Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (821-48-7) |
Safety information for Bis(2-chloroethyl)amine hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H290:Corrosive to Metals H302:Acute toxicity,oral H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Bis(2-chloroethyl)amine hydrochloride
Bis(2-chloroethyl)amine hydrochloride manufacturer
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