Betamethasone 17,21-dipropionate
Synonym(s):9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate;Betamethasone 17,21-dipropionate
- CAS NO.：5593-20-4
- Empirical Formula: C28H37FO7
- Molecular Weight: 504.6
- MDL number: MFCD00072035
- EINECS: 227-005-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is Betamethasone 17,21-dipropionate?
Chemical properties
Betamethasone 17,21-dipropionate is Pale Yellow Foam
Originator
Betnovate,Glaxo,UK,1961
The Uses of Betamethasone 17,21-dipropionate
Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.
The Uses of Betamethasone 17,21-dipropionate
antiviral
The Uses of Betamethasone 17,21-dipropionate
Cortico Steroids
What are the applications of Application
Betamethasone Dipropionate is a glucocorticoid
Definition
Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.
Manufacturing Process
A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'-
ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid
(20 ml), containing 2 drops of water, was allowed to stand at room
temperature for 5 hours. Dilution of the mixture with water gave a white solid
(457 mg) which, after being filtered off and dried, was recrystallized from
acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α-
propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with
propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and
acidification with dilute hydrochloric acid gave the crude diester.
Recrystallization from acetone-petroleum ether afforded betamethasone
17,21-dipropionate (649 mg), MP 117°C (decomposition).
brand name
Alphatrex (Savage); Diprolene (Schering).
Therapeutic Function
Glucocorticoid
Biochem/physiol Actions
Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.
Safety Profile
Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.
Properties of Betamethasone 17,21-dipropionate
| Melting point: | 178 °C |
| Boiling point: | 603.2±55.0 °C(Predicted) |
| alpha | D26 +65.7° (dioxane) |
| Density | 1.1481 (estimate) |
| refractive index | 69 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in acetone and in methylene chloride, sparingly soluble in ethanol (96 per cent). |
| form | neat |
| pka | 12.87±0.70(Predicted) |
| form | Solid |
| color | White to Pale Yellow |
| Merck | 1180 |
| CAS DataBase Reference | 5593-20-4(CAS DataBase Reference) |
Safety information for Betamethasone 17,21-dipropionate
| Signal word | Danger |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Betamethasone 17,21-dipropionate
| InChIKey | CIWBQSYVNNPZIQ-JCOVECCMSA-N |
| SMILES | C([C@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)OC(=O)CC)(=O)COC(=O)CC |&1:1,2,4,6,16,18,20,23,r| |
Betamethasone 17,21-dipropionate manufacturer
Samchem India
Gia Pharma
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