Betamethasone 17,21-dipropionate

Chemical properties

Betamethasone 17,21-dipropionate is Pale Yellow Foam

Originator

Betnovate,Glaxo,UK,1961

The Uses of Betamethasone 17,21-dipropionate

Betamethasone 17,21-dipropionate is used as anti-inflammatory and antibacterial ointment for dermatosis.

The Uses of Betamethasone 17,21-dipropionate

antiviral

The Uses of Betamethasone 17,21-dipropionate

Cortico Steroids

What are the applications of Application

Betamethasone Dipropionate is a glucocorticoid

Definition

Betamethasone 17,21-dipropionate is a steroid ester that is betamethasone in which the hydroxy hydrogens at positions 17 and 21 are replaced by propanoyl groups. It is used in combination with calcipotriene hydrate, a synthetic vitamin D analogue, for the topical treatment of plaque psoriasi in adult patients.

Manufacturing Process

A solution of 9α-fluoro-11β-hydroxy-16β-methyl-17α,21-(1'-ethyl-1'- ethoxymethylenedioxy)pregna-1,4-diene-3,20-dione (538 mg) in acetic acid (20 ml), containing 2 drops of water, was allowed to stand at room temperature for 5 hours. Dilution of the mixture with water gave a white solid (457 mg) which, after being filtered off and dried, was recrystallized from acetone to afford 9α-fluoro-11β,21-dihydroxy-16β-methyl-17α- propionyloxypregna-1,4-diene-3, 20-dione (361 mg), MP 230°-235°C.
Bethmethasone 17-propionate (812 mg) in pyridine (10 ml) was treated with propionyl chloride (0.21 ml) at 0°C for 1 hour. Dilution with water and acidification with dilute hydrochloric acid gave the crude diester. Recrystallization from acetone-petroleum ether afforded betamethasone 17,21-dipropionate (649 mg), MP 117°C (decomposition).

brand name

Alphatrex (Savage); Diprolene (Schering).

Therapeutic Function

Glucocorticoid

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits toxic fumes of F-.