4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
- CAS NO.：190728-25-7
- Empirical Formula: C17H16N2O3
- Molecular Weight: 296.32
- MDL number: MFCD19685633
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-07-24 18:13:46
What is 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline?
The Uses of 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.
Chemical Reactivity
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.
Properties of 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
| Melting point: | 211.0 to 215.0 °C |
| Boiling point: | 481.8±45.0 °C(Predicted) |
| Density | 1.246±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly) |
| form | powder to crystal |
| pka | 6.79±0.30(Predicted) |
| color | Light yellow to Brown |
| InChI | InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3 |
Safety information for 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
| InChIKey | VXEQRXJATQUJSN-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1 |
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
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