BENFLUOREX HYDROCHLORIDE

Chemical properties

White Solid

Originator

Mediator,Servier,France,1976

The Uses of BENFLUOREX HYDROCHLORIDE

BENFLUOREX HYDROCHLORIDE can be used as an antihyperlipoproteinemic therapeutic and increase of glucose penetration and use by cells.

The Uses of BENFLUOREX HYDROCHLORIDE

Hypolipedimic;Increase of glucose penetration and use by cells

What are the applications of Application

Benfluorex Hydrochloride is a compound with hypolipidermic and hypoglycemic properties

Manufacturing Process

To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β- hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were added successively 15 parts of 4.7N hydrochloric ether and a solution of 14 parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from 230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)- 2-(β-benzoyloxyethyl)amino propane hydrochloride melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts ether are added, then 10 parts of a concentrated solution of ammonium hydroxide. The mixture is stirred a few minutes until the salt is dissolved, then the ethered solution is poured off and dried. After the ether is eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β- benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.

Therapeutic Function

Antihyperlipidemic, Cardiovascular