BCI-121

Synonym(s):4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide;BCI121

CAS NO.：432529-82-3
Empirical Formula: C14H18BrN3O2
Molecular Weight: 340.22
MDL number: MFCD02149239
Update Date: 2026-04-21 10:31:43

What is BCI-121?

Biochem/physiol Actions

BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells; 100 μM BCI-121 for 48 h), downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures (46%/HT29 and 54%/HCT116 proliferation reduction; 100 μM BCI-121 for 72 h) with little antiproliferation efficacy toward low SMYD3-expressing cancer cells. BCI-121 targets SMYD3 via direct affinity interaction (kon 357.7/M/s; koff 4.23×10-3/s; KD=koff/kon = 11.8 μM) and effectively competes against histone for SMYD3 binding (%inhibition/[histone H4 peptide]:[BCI-121] ratio = 36.5%/1:1 and 51.0%/1:2.5).

Properties of BCI-121

Boiling point:	576.1±50.0 °C(Predicted)
Density	1.474±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF:30.0(Max Conc. mg/mL);88.18(Max Conc. mM) DMSO:66.0(Max Conc. mg/mL);193.99(Max Conc. mM) DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.97(Max Conc. mM) Ethanol:39.0(Max Conc. mg/mL);114.63(Max Conc. mM)
pka	13.82±0.70(Predicted)
form	powder
color	white to beige

Safety information for BCI-121

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for BCI-121

New Products

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