BAX INHIBITOR PEPTIDE P5

The Uses of BAX INHIBITOR PEPTIDE P5

Bax Inhibitor Peptide P5 is a cell-permeable pentapeptide based on the Ku70-Bax inhibiting domain. Acts as an effective Inhibitor for Bax-mediated apoptosis (~50-200 uM).

Biological Activity

bax inhibitor peptide p5 (bip p5) is a peptide inhibitor of bax translocation to mitochondria [1].bax is a pro-apoptotic member of bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. bax stays in the cytosol and transfers into mitochondria after apoptotic stimuli [1].bip p5 is a membrane-permeable peptide inhibitor of bax translocation to mitochondria. in hela cells, bip p5 protected cells from uvc- and sts-induced apoptosis. in u87-mg glioma cells, mcf-7 breast cancer cells and lncap prostate cancer cells, bip p5 also inhibited apoptosis induced by anti-cancer drugs cisplatin, etoposide and doxorubicin. while bip p5 did not suppress uvc- or sts-induced apoptosis in bax-deficient cells (du145), which suggested bip p5 only suppressed bax-mediated apoptosis. the caspase activation and the release of cytochrome c from mitochondria triggered by apoptotic stimuli were also significantly inhibited by bip p5. bip p5 inhibited the interaction of ku70 and endogenous bax in a dose-dependent way [1].

References

[1]. sawada m, hayes p, matsuyama s. cytoprotective membrane-permeable peptides designed from the bax-binding domain of ku70. nat cell biol, 2003, 5(4): 352-357.