Azithromycin dihydrate

Synonym(s):N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A;CP-62993

CAS NO.：117772-70-0
Empirical Formula: C38H74N2O13
Molecular Weight: 767.01
MDL number: MFCD01862248
EINECS: 641-134-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

What is Azithromycin dihydrate?

Chemical properties

White Solid

The Uses of Azithromycin dihydrate

Azithromycin dihydrate has anti-immunomodulatory/anti-inflammatory properties, which make it useful in treating cystic fibrosis. It shows an azalide antimicrobial agent active in vitro against various pathogens.

The Uses of Azithromycin dihydrate

Semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.

The Uses of Azithromycin dihydrate

H1 antihistamine, nonsedating

Definition

ChEBI: Azithromycin dihydrate is a hydrate. It contains an azithromycin.

brand name

Zithromax (Pfizer); Zmax (Pfizer).

Biochem/physiol Actions

Azithromycin dihydrate is a macrolide antibiotic, azalide subclass. It binds to the 50S subunit of the 70S bacterial ribosomes and inhibits RNA-dependent protein synthesis in bacterial cells. Azithromycin also has anti-immunomodulatory/anti-inflammatory properties, which make it useful in treating cystic fibrosis.

Azithromycin dihydrate application

Azithromycin Dihydrate is an azalide antimicrobial agent active in vitro against various pathogens.

Indications

Azithromycin dihydrate is a broad-spectrum macrolide antibiotic, it is effective against various gram-negative and gram-positive bacteria. It has also displayed efficacy against certain Mycoplasma species. It also exhibits anti-inflammatory and immunosuppressive properties.

Side Effects

Most common adverse reactions of azithromycin dihydrate are diarrhea (5 to 14%), nausea (3 to 18%), abdominal pain (3 to 7%), or vomiting (2 to 7%).

Properties of Azithromycin dihydrate

Melting point:	126 C
Boiling point:	717℃
alpha	D26 -41.4° (c = 1 in CHCl3)
refractive index	-47 ° (C=2, EtOH)
RTECS	RN6960000
Flash point:	>110°(230°F)
storage temp.	room temp
solubility	Soluble in DMSO at 20mg/ml. Also soluble in chloroform or ethylene chloride
form	powder
color	off-white
Sensitive	Air Sensitive
Merck	14,915
EPA Substance Registry System	1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-?-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-D-xylo-hexopyranosyl]oxy]-, dihydrate, (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)- (117772-70-0)

Safety information for Azithromycin dihydrate

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H317:Sensitisation, Skin H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.