AZD2461
Synonym(s):4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone;4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one;AZD 2461;AZD-2461
- CAS NO.：1174043-16-3
- Empirical Formula: C22H22FN3O3
- Molecular Weight: 395.43
- MDL number: MFCD24386811
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-08-05 09:01:00
What is AZD2461?
The Uses of AZD2461
4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one is a phthalazinone derivative and potential PARP inhibitor.
Biochem/physiol Actions
AZD2461, an olaparib analog, is an orally available, potent and selective PARP1 and PARP2 inhibitor that is a poor substrate for drug transporters. AZD2461 exhibits a high efficacy in olaparib-resistant tumors that overexpress P-glycoprotein.
Storage
Store at -20°C
Properties of AZD2461
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | insoluble in H2O; ≥16.35 mg/mL in DMSO; ≥45.2 mg/mL in EtOH with ultrasonic |
| pka | 12.07±0.40(Predicted) |
| form | powder |
| color | white to beige |
Safety information for AZD2461
Computed Descriptors for AZD2461
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