AS-2077715

CAS NO.：1637356-98-9
Empirical Formula: C25H41NO7
Molecular Weight: 467.6
Update Date: 2025-04-17 18:22:24

What is AS-2077715?

Biological Activity

AS-2077715 is a fungal metabolite and an inhibitor of fungal mitochondrial complex III (cytochrome bc1; IC50 = 80 ng/ml for T. mentagrophytes complex III).1 It is selective for fungal over mammalian complex III (IC50s = 480 and 860 ng/ml for murine EL-4 cell and human Jurkat cell complex III, respectively). AS-2077715 inhibits ATP production in (IC50 = 0.33 μg/ml) and is fungicidal against T. mentagrophytes when used at concentrations of 1 and 10 μg/ml. In vivo, AS-2077715 (10 and 20 mg/kg) reduces the number of foot pad skin colony forming units (CFUs) in a guinea pig model of T. mentagrophytes infection.2

References

1.Ohsumi, K., Watanabe, M., and Fujie, A.AS2077715 Is a selective inhibitor of fungal mitochondrial cytochrome Bc? complexJ. Antibiot. (Tokyo)67(10)713-716(2014) 2.Ohsumi, K., Murai, H., Nakamura, I., et al.Therapeutic efficacy of AS2077715 against experimental tinea pedis in guinea pigs in comparison with terbinafineJ. Antibiot. (Tokyo)67(10)717-719(2014)

Properties of AS-2077715

Boiling point:	622.9±55.0 °C(Predicted)
Density	1.274±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
form	A solid
pka	4.50±1.00(Predicted)

Safety information for AS-2077715

Computed Descriptors for AS-2077715

New Products

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