ARS-1620
- CAS NO.：1698055-85-4
- Empirical Formula: C21H17ClF2N4O2
- Molecular Weight: 430.84
- MDL number: MFCD31619312
- Update Date: 2025-12-05 14:33:18
What is ARS-1620?
The Uses of ARS-1620
ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
Definition
ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent.
Properties of ARS-1620
| Boiling point: | 614.7±55.0 °C(Predicted) |
| Density | 1.434±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM) |
| form | A solid |
| pka | 6.03±0.35(Predicted) |
| color | Off-white to light yellow |
Safety information for ARS-1620
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ARS-1620
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