ARRY-424704, ARRY-704
- CAS NO.：869357-68-6
- Empirical Formula: C16H17FIN3O4
- Molecular Weight: 461.23
- MDL number: MFCD18384989
- EINECS: 642-441-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:47:16
What is ARRY-424704, ARRY-704?
Description
AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells. AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.
The Uses of ARRY-424704, ARRY-704
AZD8330 is an orally active and selective MEK inhibitor.
What are the applications of Application
AZD8330 is an antineoplastic selective MEK inhibitor
Definition
ChEBI: 2-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-3-pyridinecarboxamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
References
1. feng k, wang c, zhou h, yang j, dong l, zhou k, et al. [effect of erk1/2 inhibitor azd8330 on human burkitt's lymphoma cell line raji cells and its mechanism]. zhonghua xue ye xue za zhi 2015,36:148-152.2. cohen rb, aamdal s, nyakas m, cavallin m, green d, learoyd m, et al. a phase i dose-finding, safety and tolerability study of azd8330 in patients with advanced malignancies. eur j cancer 2013,49:1521-1529.
Properties of ARRY-424704, ARRY-704
| Density | 1.732 |
| storage temp. | Store at -20°C |
| solubility | ≥23.05 mg/mL in DMSO; insoluble in H2O; ≥46.1 mg/mL in EtOH |
| form | solid |
| pka | 14.31±0.10(Predicted) |
| color | Off-white to pink |
Safety information for ARRY-424704, ARRY-704
Computed Descriptors for ARRY-424704, ARRY-704
New Products
Tridecanoic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 2-Cyanopyrimidine Xanthene-9-carboxylic acid Methyl 4-amino-2,3-difluoro-5-nitrobenzoate 4,4-Diethoxybutanenitrile 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-oneRelated products of tetrahydrofuran
![6-Amino-N-[3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenyl]-3-pyridinecarboxamide](https://img.chemicalbook.in/CAS2/GIF/371942-69-7.gif)
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