ARRY-380
- CAS NO.：937265-83-3
- Empirical Formula: C29H27N7O4S
- Molecular Weight: 569.63
- MDL number: MFCD22420817
- EINECS: 813-083-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-20 19:14:41
What is ARRY-380?
Description
Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).
The Uses of ARRY-380
ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.
The Uses of ARRY-380
Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.
What are the applications of Application
Arry-380 is a potent, selective, small-molecule tyrosine kinase HER2 inhibitor
References
[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca.
[2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com
[3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.
Properties of ARRY-380
| Density | 1.43 |
| storage temp. | Store at -20°C |
| solubility | ≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | solid |
| pka | 6.34±0.19(Predicted) |
| color | Light brown to brown |
Safety information for ARRY-380
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ARRY-380
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