Anti-XLRS1

The Uses of Anti-XLRS1

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

General Description

Retinoschisin 1 (RS1) is a localized in the retina and pineal. Its is encoded by the X-linked retinoschisis (XLRS) gene and is 24 kDa. It consists of a signal sequence, RS1 domain, discoidin domain and a C-terminal domain. It is secreted by the retinal neurons as a homo-octameric complex.

Biochem/physiol Actions

Retinoschisin 1 (RS1) plays a role in binding of β-2-laminin, αβ-crystallin, phospholipid, galactose and Na/K ATPase?SARM1 (Sterile alpha and TIR motif-containing protein 1) complex. Mutations in the RS1 gene leads to a condition called as X-linked juvenile retinoschisis which leads to macular degradation in males and deterioration of vision.