Anti-feline leukemia virus subgroup C cellular receptor 1

The Uses of Anti-feline leukemia virus subgroup C cellular receptor 1

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General Description

The gene FLVCR1 (feline leukemia virus subgroup C cellular receptor 1) is mapped to human chromosome 1q32. The gene encodes two proteins, FLVCR1a (a heme exporter in the plasma membrane) and FLVCR1b (a heme exporter in the mitochondria). FLVCR1a has 12 transmembrane domains and FLVCR1b has six transmembrane domains.

Biochem/physiol Actions

Both isoforms of FLVCR1 (feline leukemia virus subgroup C cellular receptor 1) help in maintaining heme concentration, thereby allowing proper expansion and differentiation of erythroid precursors. Downregulation or absence of FLVCR1′s activity results in diamond-Blackfan anemia. FLVCR1a was first recognized as a membrane receptor for feline leukemia virus subgroup C. Absence of FLVCR1a in mice causes hemorrhages, edema and skeletal abnormalities. On the other hand, absence of FLVCR1b results in mitochondrial heme accumulation and defects in erythroid differentiation. Mutation in the FLVCR1 gene is associated with posterior column ataxia and retinitis pigmentosa (PCARP).