Anti-Collagen α-1(III) chain precursor antibody produced in rabbit

The Uses of Anti-Collagen α-1(III) chain precursor antibody produced in rabbit

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

Biochem/physiol Actions

COL3A1 (collagen, type III, α 1) encodes the pro-α1 chains of type III collagen. This type III collagen is found in most soft connective tissues along with type I collagen. It is found in tissues such as skin, lung, uterus, intestine and the vascular system. It plays a role in the regulation of cortical development. It binds to GPR56 receptor in the brain and inhibits neuronal migration. It facilitates the coupling of GPR56 (G-protein coupled receptor) to Gα12/13 and activates the RhoA pathway. Defects in this gene cause Ehlers-Danlos syndrome types IV, with aortic and arterial aneurysms.