ANTI-CALPASTATIN

Synonym(s):Anti-BS-17;Anti-Calpain inhibitor;Anti-Calpastatin isoform a;Anti-MGC9402;Anti-PLACK

Molecular Weight: 0
MDL number: MFCD00164555
Update Date: 2025-01-27 09:38:02

What is ANTI-CALPASTATIN?

The Uses of ANTI-CALPASTATIN

Monoclonal Anti-Calpastatin antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:200 and for western blotting at a dilution of 1:5,000.

General Description

Calpastatin is a protein encoded by the CAST gene in humans. Calpastatin is an endogenous inhibitor of the ubiquitous calcium dependent proteinases μ- and m-calpain. It plays a key role in many cellular physiological and pathological processes. Calpastatin level is very important for controlling calpain activity.

Biochem/physiol Actions

Calpastatin availability in cytosol is controlled by Ca2+ and cyclic AMP. Prolonged calpain activation promotes degradation of calpastatin. Calpastatin is found to be overexpressed in mycoplasma-contaminated cultured cells. CAST gene is found to be involved in genetic susceptibility to Keratoconus (KC), a genetically heterogeneous corneal dystrophy. It is also found to be associated with Parkinson′s disease (PD) and single nucleotide polymorphisms (SNPs).

Properties of ANTI-CALPASTATIN

storage temp.	−20°C
form	buffered aqueous solution

Safety information for ANTI-CALPASTATIN

Computed Descriptors for ANTI-CALPASTATIN

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