ANTI-ACTIVATING SIGNAL COINTEGRATOR-2

The Uses of ANTI-ACTIVATING SIGNAL COINTEGRATOR-2

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

LRP6 (low-density lipoprotein receptor-related protein 6) belongs to the LDL (low-density lipoprotein) receptor family. It is expressed in type II skeletal muscle fibers.

Biochem/physiol Actions

LRP6 (low-density lipoprotein receptor-related protein 6) controls glucose metabolism in human skeletal muscles. It even modulates body fat and glucose homeostasis in adipose and hepatic tissues. LRP6 interacts with caveolin-1 and enhances insulin-like growth factor-I receptor and insulin receptor signaling, thereby leading to aerobic glycolysis.