Androstenedione

CAS NO.：63-05-8
Empirical Formula: C19H26O2
Molecular Weight: 286.41
MDL number: MFCD00003615
EINECS: 200-554-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-13 11:26:18

What is Androstenedione?

Description

Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical properties

White to Off-White Solid

The Uses of Androstenedione

Testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic sterid)

Definition

ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.

Safety Profile

An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Purification Methods

Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.]

Properties of Androstenedione

Melting point:	170-171 °C(lit.)
Boiling point:	368.77°C (rough estimate)
alpha	D30 +199° (in chloroform)
Density	1.0655 (rough estimate)
refractive index	1.4709 (estimate)
Flash point:	2℃
storage temp.	Controlled Substance, -20°C Freezer
solubility	Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Sparingly)
form	Solid
color	Dimorphous: Needles from acetone, or crystalsfrom hexane
Water Solubility	57.28mg/L(25 ºC)
Merck	13,643
CAS DataBase Reference	63-05-8(CAS DataBase Reference)
NIST Chemistry Reference	Androst-4-ene-3,17-dione(63-05-8)
EPA Substance Registry System	4-Androstenedione (63-05-8)

Safety information for Androstenedione

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.