Amino-PEG4-CH2CO2H
- CAS NO.：195071-49-9
- Empirical Formula: C10H21NO6
- Molecular Weight: 251.28
- MDL number: MFCD27977508
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 06:27:47
What is Amino-PEG4-CH2CO2H?
Description
Amino-PEG4-CH2CO2H is a PEG linker containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
The Uses of Amino-PEG4-CH2CO2H
Amino-PEG4-CH2CO2H is an important biological reagent for the synthesis of PROTAC and antibody-drug couplings (ADCs). It is also used to prepare Masp inhibitory compounds, Mertk degraders and pyruvate kinase inhibitors.
Properties of Amino-PEG4-CH2CO2H
| Boiling point: | 397.6±32.0 °C(Predicted) |
| Density | 1.156±0.06 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO : 100 mg/mL (397.96 mM; Need ultrasonic) |
| pka | 3.39±0.10(Predicted) |
| color | White |
Safety information for Amino-PEG4-CH2CO2H
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Amino-PEG4-CH2CO2H
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