AMD 3465 (Hexahydrobromide)

Synonym(s):AMD 3465;GENZ-644494;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

CAS NO.：185991-07-5
Empirical Formula: C24H39BrN6
Molecular Weight: 491.52
MDL number: MFCD20926342
SAFETY DATA SHEET (SDS)
Update Date: 2026-06-03 11:24:09

AMD 3465 (*Hexahydrobromide*) Structural

What is AMD 3465 (Hexahydrobromide)?

The Uses of AMD 3465 (Hexahydrobromide)

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

What are the applications of Application

AMD 3465 hexahydrobromide is a selective and potent CXCR4 antagonist

Biochem/physiol Actions

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.

Storage

Store at -20°C

Properties of AMD 3465 (Hexahydrobromide)

Melting point:	>200°C (dec.)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
form	powder
color	white to light brown

Safety information for AMD 3465 (Hexahydrobromide)

Computed Descriptors for AMD 3465 (Hexahydrobromide)

New Products

Pentadecanoic acid 3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetrahydropyranyl-4-acetic acid Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 5-fluoro-1,3-benzodioxole 2-Bromo-6-fluoroaniline 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinoline 2-(Chloromethyl) quinazolin-4(3H)-one

AMD 3465 (*Hexahydrobromide*)

Synonym(s):AMD 3465;GENZ-644494;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

What is AMD 3465 (*Hexahydrobromide*)?

The Uses of AMD 3465 (*Hexahydrobromide*)