AMD 3465 (*Hexahydrobromide*)
Synonym(s):AMD 3465;GENZ-644494;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
- CAS NO.：185991-07-5
- Empirical Formula: C24H39BrN6
- Molecular Weight: 491.52
- MDL number: MFCD20926342
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is AMD 3465 (*Hexahydrobromide*)?
The Uses of AMD 3465 (*Hexahydrobromide*)
AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma
What are the applications of Application
AMD 3465 hexahydrobromide is a selective and potent CXCR4 antagonist
Biochem/physiol Actions
AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.
Storage
Store at -20°C
Properties of AMD 3465 (*Hexahydrobromide*)
| Melting point: | >200°C (dec.) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Very Slightly), Water (Slightly) |
| form | powder |
| color | white to light brown |
Safety information for AMD 3465 (*Hexahydrobromide*)
Computed Descriptors for AMD 3465 (*Hexahydrobromide*)
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