Alvimopan
- CAS NO.：156053-89-3
- Empirical Formula: C25H32N2O4
- Molecular Weight: 424.53
- MDL number: MFCD25970564
- EINECS: 1312995-182-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 15:00:32
What is Alvimopan?
Absorption
Alvimopan's high affinity for the peripheral mu-receptor leads to slower absorption dependent on dissociation from the receptor and subsequently low oral bioavailability of less than 7%.
The Uses of Alvimopan
flavenoid cytoprotective agent for the treatment of mucosal lesions
The Uses of Alvimopan
A peripheral μ-opioid receptor antagonist. Gastroprokinetic.
Definition
ChEBI: Alvimopan is a peptide.
What are the applications of Application
Alvimopan is a gastroprokinetic, peripheral μ-opioid receptor antagonist.
Background
Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.
Indications
Used to accelerate the time to upper and lower gastrointestinal recovery following partial large or small bowel resection surgery with primary anastomosis. Also investigated for use in the treatment of pain (acute or chronic).
Metabolism
Alvimopan is primarily metabolized by intestinal flora to an active metabolite although it has no clinically significant contribution to the effects of the drug.
Properties of Alvimopan
| Melting point: | 200-204°C |
| Boiling point: | 684.1±55.0 °C(Predicted) |
| Density | 1.166±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated, Heated) |
| form | Solid |
| pka | 3.39±0.10(Predicted) |
| color | White |
Safety information for Alvimopan
Computed Descriptors for Alvimopan
Alvimopan manufacturer
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