Aldehyde Reactive Probe (trifluoroacetate salt)

CAS NO.：627090-10-2
Empirical Formula: C14H22F3N5O6S
Molecular Weight: 445.41
MDL number: MFCD03427750
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-04 14:24:59

What is Aldehyde Reactive Probe (trifluoroacetate salt)?

Description

DNA is continually damaged by endogenous and environmental agents leading to the formation of abasic (apurinic/apyrimidinic, AP) sites that are disruptive to DNA synthesis. Aldehyde Reactive Probe (ARP) is a biotinylated reagent for the detection and quantification of AP sites in damaged DNA. ARP reacts with aldehyde groups formed when reactive oxygen species depurinate DNA, resulting in covalent linkage of biotin to these AP sites. The biotin-tagged DNA can then be detected using common avidin-conjugated reporters such as avidin-HRP. The ARP method is highly sensitive, enabling detection of 2.4 AP sites per 1x107 nucleotides of DNA.

Properties of Aldehyde Reactive Probe (trifluoroacetate salt)

storage temp.	Store at -20°C
solubility	DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml
form	A crystalline solid

Safety information for Aldehyde Reactive Probe (trifluoroacetate salt)

Computed Descriptors for Aldehyde Reactive Probe (trifluoroacetate salt)

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