Adenanthin
- CAS NO.：111917-59-0
- Empirical Formula: C26H34O9
- Molecular Weight: 490.55
- MDL number: MFCD20260622
- SAFETY DATA SHEET (SDS)
What is Adenanthin?
Enzyme inhibitor
This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid.
Properties of Adenanthin
| Boiling point: | 593.4±50.0 °C(Predicted) |
| Density | 1.29±0.1 g/cm3(Predicted) |
| pka | 14.13±0.70(Predicted) |
Safety information for Adenanthin
Computed Descriptors for Adenanthin
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