ACLARUBICIN HYDROCHLORIDE

CAS NO.：75443-99-1
Empirical Formula: C42H54ClNO15
Molecular Weight: 848.33
MDL number: MFCD00133024
EINECS: 278-209-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:03

What is ACLARUBICIN HYDROCHLORIDE?

Definition

ChEBI: Aclarubicin hydrochloride is an anthracycline.

Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.

in vitro

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

in vivo

Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD ₅₀ (76.5 mg/kg) is about twice the iv LD ₅₀ (35.6 mg/kg) in mice ^[4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model ^[4 .

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Animal Model:	DBA/2, CDF ₁ ( BALB/c×DBA/2) mice with Leukemia P-388 ^[4 .
Dosage:	0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration:	Intraperit oneal administration daily for 10 days starting 3 hr after transplantation.
Result:	Inhibited tumor growth.

Properties of ACLARUBICIN HYDROCHLORIDE

Melting point:	151-153℃
Boiling point:	898℃
Flash point:	>110°(230°F)
storage temp.	2-8°C
solubility	Soluble in DMSO or DMF at 25mg/ml
form	Solid
color	Light yellow to yellow

Safety information for ACLARUBICIN HYDROCHLORIDE

Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up.