AC-YVAD-CHO

Synonym(s):Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem;IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049

CAS NO.：143313-51-3
Empirical Formula: C23H32N4O8
Molecular Weight: 492.52
MDL number: MFCD00237123
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:06

What is AC-YVAD-CHO?

Description

Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; K_i = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (K_is = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (K_is = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.

The Uses of AC-YVAD-CHO

A potent, specific, and reversible inhibitor of caspases-1, -4 and -5

What are the applications of Application

Caspase-1 inhibitor I is an inhibitor of caspase-1, caspase-4, and caspase-5

Properties of AC-YVAD-CHO

Boiling point:	937.7±65.0 °C(Predicted)
Density	1.276±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM)
form	Powder
pka	4.20±0.10(Predicted)
color	White to off-white
Sensitive	Moisture Sensitive