A549 CELLS EGFR BIOSENSOR
- Molecular Weight: 0
- Update Date: 2025-01-27 09:38:02
What is A549 CELLS EGFR BIOSENSOR?
The Uses of A549 CELLS EGFR BIOSENSOR
The EGFR Biosensor cell line consists of the SH2 domain of the adaptor protein Grb2 fused to GFP. The biosensor was transduced into the A549 cell line and a stable cell line was cloned from a single cell. Within minutes after stimulation of the cell line with EGF, the biosensor shows robust redistribution towards the cell membrane and subsequent internalization through endocytosis. The internalization kinetics of the sensor-receptor complex can be quantified by image analysis software to count granules. The reporter response is highly selective as it can be induced only by specific EGFR ligands and is abolished by a selective inhibitor of EGFR, Tyrphostin AG 1478.
General Description
This cell line was derived from ATCC catalog No. CCL-185.
Properties of A549 CELLS EGFR BIOSENSOR
| storage temp. | -196°C |
Safety information for A549 CELLS EGFR BIOSENSOR
Computed Descriptors for A549 CELLS EGFR BIOSENSOR
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