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HomeProduct name listDIMETHYL DL-GLUTAMATE HYDROCHLORIDE

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

DIMETHYL DL-GLUTAMATE HYDROCHLORIDE Structural Picture

What is DIMETHYL DL-GLUTAMATE HYDROCHLORIDE?

Description

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

The Uses of DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles. Dimethyl DL-glutamate Hydrochloride is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes. It also potentiates the insulinotropic potential of glyburide and glucagon-like peptide 1. Dimethyl DL-glutamate Hydrochloride is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells. However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.

Properties of DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

Melting point: 154 °C
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form  Solid
color  White to Off-White

Safety information for DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

Computed Descriptors for DIMETHYL DL-GLUTAMATE HYDROCHLORIDE

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