7-HYDROXYFLAVONE
Synonym(s):7-Hydroxy-2-phenyl-4H-1-benzopyran-4-one;NSC 94258
- CAS NO.：6665-86-7
- Empirical Formula: C15H10O3
- Molecular Weight: 238.24
- MDL number: MFCD00006835
- EINECS: 229-705-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-10-29 15:43:00
What is 7-HYDROXYFLAVONE?
Chemical properties
off-white crystals
The Uses of 7-HYDROXYFLAVONE
antifungal, analgesic
The Uses of 7-HYDROXYFLAVONE
Reactant:
- Acting as a biologically valuable acceptor in O-glycosidation reactions
- Involved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitors
- For O-methylation with di-Me carbonate
- Linked by a polymethylene chain for synthesis of α1-adrenoceptor antagonists
- Involved in Baylis-Hillman reactions
- Involved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids
What are the applications of Application
7-Hydroxyflavone is involved in synthesis of fully phosphorylated flavones
Definition
ChEBI: 7-hydroxyflavone is a hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4
Biological Activity
7-Hydroxyflavone is a flavonoid isolated from M. indica with anti-inflammatory properties. It protects renal cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway.
Properties of 7-HYDROXYFLAVONE
| Melting point: | 245-247 °C (lit.) |
| Boiling point: | 320.83°C (rough estimate) |
| Density | 1.340±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5740 (estimate) |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| Water Solubility | Insoluble in water |
| pka | 7.02±0.40(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| BRN | 194089 |
| CAS DataBase Reference | 6665-86-7(CAS DataBase Reference) |
Safety information for 7-HYDROXYFLAVONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 7-HYDROXYFLAVONE
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