6,2',4'-TRIMETHOXYFLAVONE

Synonym(s):2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one;TMF;Trimethoxyflavone

CAS NO.：720675-90-1
Empirical Formula: C18H18O5
Molecular Weight: 314.33
MDL number: MFCD03412381
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 01:16:29

What is 6,2',4'-TRIMETHOXYFLAVONE?

What are the applications of Application

6,2′,4′-Trimethoxyflavone is an aryl hydrocarbon receptor inhibitor

Biochem/physiol Actions

6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.

Properties of 6,2',4'-TRIMETHOXYFLAVONE

Boiling point:	482.8±45.0 °C(Predicted)
Density	1.208±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: >5mg/mL
form	powder
color	yellow

Safety information for 6,2',4'-TRIMETHOXYFLAVONE

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..…

Computed Descriptors for 6,2',4'-TRIMETHOXYFLAVONE

New Products

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