6-O-Benzylguanine

CAS NO.：19916-73-5
Empirical Formula: C12H11N5O
Molecular Weight: 241.25
MDL number: MFCD00269931
EINECS: 1592732-453-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-05 17:56:54

What is 6-O-Benzylguanine?

Chemical properties

Light Yellow Solid

The Uses of 6-O-Benzylguanine

An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents.

The Uses of 6-O-Benzylguanine

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

What are the applications of Application

O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase

Biochem/physiol Actions

O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.

Properties of 6-O-Benzylguanine

Melting point:	193(dec.)
Boiling point:	459.3±55.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	room temp
solubility	methanol: 20 mg/mL
form	solid
pka	7.47±0.20(Predicted)
color	Off-White to Light Yellow
CAS DataBase Reference	19916-73-5(CAS DataBase Reference)

Safety information for 6-O-Benzylguanine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.