6-Methylthioguanine
Synonym(s):2-Amino-6-methylthiopurine
- CAS NO.：1198-47-6
- Empirical Formula: C6H7N5S
- Molecular Weight: 181.22
- MDL number: MFCD00044701
- EINECS: 214-833-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:22:31
What is 6-Methylthioguanine?
Chemical properties
off-white crystalline powder
The Uses of 6-Methylthioguanine
As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
The Uses of 6-Methylthioguanine
2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.
What are the applications of Application
2-Amino-6-methylmercaptopurine is A metabolite of 2′-Deoxy-6-thio Guanosine and 6-Thioguanine
Definition
ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.
Biochem/physiol Actions
2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.
Properties of 6-Methylthioguanine
| Melting point: | 235.5°C |
| Density | 1.403 (estimate) |
| refractive index | 1.4606 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | solid |
| color | White to Off-White |
Safety information for 6-Methylthioguanine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 6-Methylthioguanine
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