6-Methoxynicotinamide

CAS NO.：7150-23-4
Empirical Formula: C7H8N2O2
Molecular Weight: 152.15
MDL number: MFCD00229166
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-20 23:19:27

What is 6-Methoxynicotinamide?

Description

JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.

Biological Activity

JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM.

in vitro

JBSNF-000088 (6-Methoxynicotinamide) has IC ₅₀ values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells.

Properties of 6-Methoxynicotinamide

Melting point:	178-180°C
Boiling point:	301.6±22.0 °C(Predicted)
Density	1.213±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly)
pka	15.17±0.50(Predicted)
form	Solid
color	Off-White to Pale Beige
InChI	InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)

Safety information for 6-Methoxynicotinamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.