6-Methoxyisoquinoline

CAS NO.：52986-70-6
Empirical Formula: C10H9NO
Molecular Weight: 159.18
MDL number: MFCD04114861
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:13:49

What is 6-Methoxyisoquinoline?

Chemical properties

Clear Oil

The Uses of 6-Methoxyisoquinoline

6-Methoxy Isoquinoline (cas# 52986-70-6) is a compound useful in organic synthesis.

Preparation

6-Methoxyisoquinoline synthesis: Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxybenzaldehyde is obtained through condensation with nitromethane Shiff base and reduction of aluminum hydride -p-Phenylethylamine. The Pictet-Spengler reaction of 3-methoxyl-p-phenylethylamine and 40% aqueous formaldehyde produces 6-methoxyl-1,2,3,4-tetrahydroisoquinoline, and then obtains the target compound in dehydrogenation 6-Methoxyisoquinoline.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 1939, 1947 DOI: 10.1021/ja01200a028

Properties of 6-Methoxyisoquinoline

Boiling point:	88-95?C/0.8 Torr
Density	1.130±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Dichloromethane
form	Oil
pka	6.11±0.10(Predicted)
color	Pale Yellow
CAS DataBase Reference	52986-70-6(CAS DataBase Reference)

Safety information for 6-Methoxyisoquinoline

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.