6-Methoxyisoquinoline
- CAS NO.：52986-70-6
- Empirical Formula: C10H9NO
- Molecular Weight: 159.18
- MDL number: MFCD04114861
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 02:30:12
What is 6-Methoxyisoquinoline?
Chemical properties
Clear Oil
The Uses of 6-Methoxyisoquinoline
6-Methoxy Isoquinoline (cas# 52986-70-6) is a compound useful in organic synthesis.
Preparation
6-Methoxyisoquinoline synthesis: Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxybenzaldehyde is obtained through condensation with nitromethane Shiff base and reduction of aluminum hydride -p-Phenylethylamine. The Pictet-Spengler reaction of 3-methoxyl-p-phenylethylamine and 40% aqueous formaldehyde produces 6-methoxyl-1,2,3,4-tetrahydroisoquinoline, and then obtains the target compound in dehydrogenation 6-Methoxyisoquinoline.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 1939, 1947 DOI: 10.1021/ja01200a028
Properties of 6-Methoxyisoquinoline
| Boiling point: | 88-95?C/0.8 Torr |
| Density | 1.130±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane |
| form | Oil |
| pka | 6.11±0.10(Predicted) |
| color | Pale Yellow |
| CAS DataBase Reference | 52986-70-6(CAS DataBase Reference) |
Safety information for 6-Methoxyisoquinoline
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Methoxyisoquinoline
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