6-Methoxy-2-naphthaldehyde
- CAS NO.：3453-33-6
- Empirical Formula: C12H10O2
- Molecular Weight: 186.21
- MDL number: MFCD00081152
- EINECS: 222-377-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:00
What is 6-Methoxy-2-naphthaldehyde?
Chemical properties
yellow to beige-yellow crystals or crystalline
The Uses of 6-Methoxy-2-naphthaldehyde
6-Methoxy-2-naphthaldehyde is used as a diagnostic reagent in tumor studies involving aldehyde dehydrogenase enzymes. In addition it is used in organic synthesis reactions forming fluoresce nt substrates for inhibition studies relating to hypertension and vascular inflammation.
The Uses of 6-Methoxy-2-naphthaldehyde
6-Methoxy-2-naphthaldehyde is used as a diagnostic reagent in tumor studies involving aldehyde dehydrogenase enzymes. In addition it is used in organic synthesis reactions forming fluorescent substrates for inhibition studies relating to hypertension and vascular inflammation. It is also used as intermediate of Nabumetone.
The Uses of 6-Methoxy-2-naphthaldehyde
6-Methoxy-2-naphthaldehyde may be used in the preparation of the following 4-(6-methoxy-2-naphthyl)butan-2-one related compounds:
- 4-(6-methoxy-2-naphthyl)but-3-en-2-one
- 4-(6-methoxy-2-naphthyl)-3-methylbutan-2-one
- 5-(6-methoxy-2-naphthyl)pentan-3-one
It may also be used in the synthesis of the following chalcone derivatives:
- (2E)-1-(2-hydroxyphenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
- (2E)-1-(2-chloropyridin-4-yl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
- (2E)-3-(6-methoxy-2-naphthyl)-1-pyridin-4-ylprop-2-en-1-one
- (2E)-1-(2,4-dichlorophenyl)-3-(6-methoxy-2-naphthyl)prop-2-en-1-one
What are the applications of Application
6-Methoxy-2-naphthaldehyde is a diagnostic reagent in tumor studies
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 4587, 1988 DOI: 10.1021/jo00254a035
General Description
6-Methoxy-2-naphthaldehyde can be prepared by reacting 2-bromo 6-methoxy naphthalene with triethylorthoformate via Grignard reaction. Its crystals belong to the orthorhombic space group, P212121 and shows excellent NLO (non-linear optical) property.
Flammability and Explosibility
Not classified
Properties of 6-Methoxy-2-naphthaldehyde
| Melting point: | 81-84 °C(lit.) |
| Boiling point: | 196 °C / 10mmHg |
| Density | 1.169±0.06 g/cm3(Predicted) |
| vapor pressure | 0.022Pa at 25℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Sonicated) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | 150.1mg/L at 25℃ |
| Sensitive | Air Sensitive |
| BRN | 1945989 |
| CAS DataBase Reference | 3453-33-6(CAS DataBase Reference) |
Safety information for 6-Methoxy-2-naphthaldehyde
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Methoxy-2-naphthaldehyde
6-Methoxy-2-naphthaldehyde manufacturer
SAKEM LLP
1Y
Phone:+91-9676889998
Whatsapp: +91-9676889998
product: 3453-33-6 6-Methoxy-2-naphthaldehyde 98%
Grindlays Pharmaceuticals Private Limited
Mumbai
product: 6-Methoxy-2-Naphthaldehyde,C12H10O2,3453-33-6, >99%,For Industrial Use
Seema Finechem Industry LLP
Mumbai
product: 6-Methoxy-2-Naphthaldehyde,C12H10O2,3453-33-6, 97%, 25/50 Drum, For Industrial Use
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