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HomeProduct name list6-Chloro-1H-pyrazolo[4,3-c]pyridine

6-Chloro-1H-pyrazolo[4,3-c]pyridine

6-Chloro-1H-pyrazolo[4,3-c]pyridine Structural

What is 6-Chloro-1H-pyrazolo[4,3-c]pyridine?

The Uses of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Used as a pharmaceutical intermediate for laboratory research and development.

Synthesis

4,6-Dichloropyridine-3-carbaldehyde (3.7 g, 32 mmol), hydrazine (3.5 mL, 110 mmol) and N,N-diisopropylethylamine (20 mL) were combined in DMA (100 mL) and stirred at 80° C. for four hours. Then, the solution was cooled to room temperature, diluted with EtOAc, and washed three times with water and then with brine. The organic solution was concentrated and the resulting mixture was precipitated from dichloromethane to give 6-chloro-1H-pyrazolo[4,3-c]pyridine. Yield 2 g (41%). LCMS (ESI): calc. C6H4ClN3=153; obs. M+H=154.
6-Chloro-1H-pyrazolo[4,3-c]pyridine synthesis

Properties of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Boiling point: 358℃
Density  1.531
Flash point: 201℃
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
pka 10.46±0.40(Predicted)
form  powder
color  Yellow
InChI InChI=1S/C6H4ClN3/c7-6-1-5-4(2-8-6)3-9-10-5/h1-3H,(H,9,10)
CAS DataBase Reference 1206979-33-0

Safety information for 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H332:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-Chloro-1H-pyrazolo[4,3-c]pyridine

InChIKey AAJIQIWPVIWCGA-UHFFFAOYSA-N
SMILES C1=NC(Cl)=CC2NN=CC1=2

6-Chloro-1H-pyrazolo[4,3-c]pyridine manufacturer

Visa Chem Private Limited

Hyderabad
product: 6 Chloro 1H Pyrazolo 4 3 C Pyridine, Grade Standard: Reagent Grade
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