5,6-DIHYDROXYINDOLE

CAS NO.：3131-52-0
Empirical Formula: C8H7NO2
Molecular Weight: 149.15
MDL number: MFCD00798933
EINECS: 412-130-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-02-27 19:53:41

What is 5,6-DIHYDROXYINDOLE?

Description

5,6-Dihydroxyindole is a melanin precursor. It is one of the toxic compounds in the melanin biosynthetic pathway. 5,6-Dihydroxyindole is an indole derivative that contains two hydroxyl groups attached to the 5th and 6th positions of the indole ring. It is an intermediate in the biosynthesis of melanin, a pigment responsible for the coloration of hair, skin, and eyes in humans and other organisms.

The Uses of 5,6-DIHYDROXYINDOLE

5,6-Dihydroxyindole is an intermediate in melanogenesis, the production of melanin which is found in our skin, eyes, hair, and inner ear.

What are the applications of Application

5,6-Dihydroxyindole is a melanin precursor

Definition

ChEBI: 5,6-dihydroxyindole is a dihydroxyindole. It has a role as a mouse metabolite.

Synthesis Reference(s)

Synthetic Communications, 15, p. 321, 1985 DOI: 10.1080/00397918508063806

Properties of 5,6-DIHYDROXYINDOLE

Melting point:	140 °C (decomp)
Boiling point:	411.2±25.0 °C(Predicted)
Density	1.510±0.06 g/cm3(Predicted)
RTECS	NL7858000
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
pka	9.81±0.40(Predicted)
form	Solid
color	Off-white to light brown
InChI	InChI=1S/C8H7NO2/c10-7-3-5-1-2-9-6(5)4-8(7)11/h1-4,9-11H

Safety information for 5,6-DIHYDROXYINDOLE

Signal word	Warning
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.