5,6-DIHYDROURACIL

Synonym(s):5,6-Dihydro-2,4-dihydroxypyrimidine

CAS NO.：504-07-4
Empirical Formula: C4H6N2O2
Molecular Weight: 114.1
MDL number: MFCD00006029
EINECS: 207-982-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-12-05 14:33:18

What is 5,6-DIHYDROURACIL?

Chemical properties

white to light beige crystalline powder

The Uses of 5,6-DIHYDROURACIL

5,6-Dihydrouracil acts as an intermediate in the catabolism of uracil.

The Uses of 5,6-DIHYDROURACIL

Impurity of Uracil.

The Uses of 5,6-DIHYDROURACIL

Dihydrouracil has been used as a standard for ureido group in the colorimentric assay of transfer ribonucleic acid (tRNA).

What are the applications of Application

5,6-Dihydrouracil is an intermediate in the catabolism of uracil

Definition

ChEBI: 5,6-dihydrouracil is a pyrimidine obtained by formal addition of hydrogen across the 5,6-position of uracil. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.

General Description

Dihydrouracil (DiHU) is a minor base found in transfer ribonucleic acid (tRNA). It is similar to uracil with the only exception that the C₅-C₆ bond is saturated. It crystallized in the monoclinic system with space group P2₁/_C. Its crystalline structure has been analyzed. Its generation from L-cysteine and uracil via photochemical addition has been described.

Properties of 5,6-DIHYDROURACIL

Melting point:	279-281 °C (lit.)
Boiling point:	213.59°C (rough estimate)
Density	1.3565 (rough estimate)
refractive index	1.4487 (estimate)
storage temp.	2-8°C
solubility	Soluble in Sodium Hydroxide.
form	Solid
pka	12.10±0.20(Predicted)
color	White to Light Beige
BRN	112496
InChI	InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8)
CAS DataBase Reference	504-07-4(CAS DataBase Reference)
EPA Substance Registry System	2,4(1H,3H)-Pyrimidinedione, dihydro- (504-07-4)

Safety information for 5,6-DIHYDROURACIL

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.