5-Methyltryptamine hydrochloride
Synonym(s):3-(2-Aminoethyl)-5-methylindole hydrochloride
- CAS NO.：1010-95-3
- Empirical Formula: C11H15ClN2
- Molecular Weight: 210.7
- MDL number: MFCD00012683
- EINECS: 213-777-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:09:40
What is 5-Methyltryptamine hydrochloride?
Chemical properties
Light Tan Solid
The Uses of 5-Methyltryptamine hydrochloride
5-Methyltryptamine hydrochloride is a methylated derivative of tryptamine, it is a weak antagonist of 5-Hydroxytryptamine (H974990) with weak potency as stimulants of the cardiac sympathetic nerves. 5-Methyltryptamine hydrochloride is also used in the preparation of inhibitors of kinesin spindle protein (KSP), a promising class of anticancer agents.
The Uses of 5-Methyltryptamine hydrochloride
- reactant in synthesis of kinesin spindle protein (KSP) inhibitors
- reactant in intramolecular furan Diels-Alder reactions
- reactant in Pictet-Spengler-like reactions
Purification Methods
Recrystallise the hydrochloride from H2O. The free base has m 96-98o (from *C6H6/cyclohexane) or m 99-100o (from pet ether), and the picrate has m 243o(dec) (from EtOH). [Young J Chem Soc 3493 1958, Gaddum et al. Quart J Exp Physiol 40 49 1955, R.hm Hoppe Seyler's Z Physiol Chem 297 229 1954, Beilstein 22 III/IV 4364, 22/10 V 167.]
Properties of 5-Methyltryptamine hydrochloride
| Melting point: | 290-292 °C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | Pale Beige to Light Tan |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 1010-95-3 |
Safety information for 5-Methyltryptamine hydrochloride
Computed Descriptors for 5-Methyltryptamine hydrochloride
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