5-Methyl-2-nitroaniline
Synonym(s):6-Nitro-m-toluidine
- CAS NO.：578-46-1
- Empirical Formula: C7H8N2O2
- Molecular Weight: 152.15
- MDL number: MFCD00007814
- EINECS: 209-423-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-09-12 18:52:02
What is 5-Methyl-2-nitroaniline?
The Uses of 5-Methyl-2-nitroaniline
5-Methyl-2-nitroaniline has been used in the preparation of N-(5-methyl-2-nitrophenyl)-4-[N-(pyridin-3-ylmethoxy carbonyl)aminomethyl]benzamide.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 4992, 1980 DOI: 10.1021/jo01312a039
General Description
Yellow leaflets (from water) or orange powder.
Air & Water Reactions
5-METHYL-2-NITROANILINE is sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile
5-METHYL-2-NITROANILINE is incompatible with acids, acid chlorides, acid anhydrides, chloroformates, and strong oxidizers .
Health Hazard
SYMPTOMS: Symptoms of exposure to 5-METHYL-2-NITROANILINE may include irritation. Structurally similar chemicals may cause methemoglobinemia.
Fire Hazard
Flash point data for 5-METHYL-2-NITROANILINE are not available; however, 5-METHYL-2-NITROANILINE is probably combustible.
Safety Profile
Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx.
Properties of 5-Methyl-2-nitroaniline
| Melting point: | 110-111 °C (lit.) |
| Boiling point: | 312.4±22.0 °C(Predicted) |
| Density | 1.269±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 0.03±0.25(Predicted) |
| BRN | 2691416 |
| CAS DataBase Reference | 578-46-1(CAS DataBase Reference) |
| EPA Substance Registry System | 5-Methyl-2-nitroaniline (578-46-1) |
Safety information for 5-Methyl-2-nitroaniline
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for 5-Methyl-2-nitroaniline
| InChIKey | IGDYNWKWXUCIJB-UHFFFAOYSA-N |
New Products
Cyclobutanone (R)-(-)-2-Amino-1-propanol Fmoc-OSu 5-bromo-4-fluoro-2-nitrobenzaldehyde 2-Amino-2-(4-methylphenyl)acetic acid 1-(2-Chloroethyl)pyrrolidine Hydrochloride 2,4-Dihydroxybenzaldehyde Obidoxime hydrochloride API Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
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