5'-FLUORO-2'-HYDROXYPROPIOPHENONE
- CAS NO.：443-09-4
- Empirical Formula: C9H9FO2
- Molecular Weight: 168.16
- MDL number: MFCD00218583
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:27:00
What is 5'-FLUORO-2'-HYDROXYPROPIOPHENONE?
Preparation
Preparation by Fries rearrangement of p-fluorophenyl propionate (b.p.18–20 118–120°) with aluminium chloride at 150° for 1 h (80–81%) or at reflux for 30 min (57%)
Also obtained by demethylation of 5-fluoro-2-methoxy-propiophenone (b.p.13 132°) with refluxing pyridinium chloride for 15 min (76%).
Properties of 5'-FLUORO-2'-HYDROXYPROPIOPHENONE
| Melting point: | 35-39 °C |
| Boiling point: | 117-121 °C(Press: 22 Torr) |
| Density | 1.200±0.06 g/cm3(Predicted) |
| Flash point: | 219 °F |
| pka | 8.26±0.48(Predicted) |
| CAS DataBase Reference | 443-09-4(CAS DataBase Reference) |
Safety information for 5'-FLUORO-2'-HYDROXYPROPIOPHENONE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5'-FLUORO-2'-HYDROXYPROPIOPHENONE
New Products
3-azanyl-3-phenyl-propanoic acid 3-AMINO-3-(2-METHYLPHENYL)PROPANOIC ACID 3-AMINO-3-M-TOLYL-PROPIONIC ACID Nitroso Irbesartan N-Nitroso Nortriptyline 1-nitro-3,5-dimethyl adamantine (NMEM) 3-(2-aminoethyl) benzene sulfonamide Nabumetone Impurity 5 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 4-dimethylaminopyridine 3-Bromo-2-Methyl-5-Nitropyridine 2-Chloro Isonicotinic acid methyl ester 2-(Ethoxymethylene)propanedinitrile 5-Bromo-3-Methyl-2-Pyridinecarboxylic acid 5-Chloro-pyridine-2-carboxylic acid amideRelated products of tetrahydrofuran
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